Future has a lot to offer for healing brain cancer. A study has been done by the scientists from Far Eastern Federal University (FEFU) in cooperation with colleagues from Blokhin Russian Cancer Research Center (Moscow), Switzerland, and Sweden on proteins which were found to constitute WNT signaling pathway of the cancer stem cells of glioblastoma multiforme (GBM CD133+ CSCs), one of the most aggressive brain tumors.
A number of proteins, which are potential targets to attack during complex antitumor therapy have been revealed by the researchers.
In medicine science Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors that is very resistant to any therapy. Due to its resistance, most of the patients diagnosed with this only can survive for just 15 months.
The survival percentage of such patients who can live more than two years is just 27% after their diagnosis. According to scientists, tumor resistance to treatment is associated with cancer stem cells, and, in particular, with the activation of WNT signaling pathways in them.
‘WNT signaling pathways in human cells are responsible for a number of important functions, including cell proliferation. It majorly responsible for their reproduction, and the ability to differentiate into other types of cells. Unfortunately, they can contribute to the proliferation of cancer cells.
It is high time in modern medicine to research about the behavior of the stem cells of glioblastoma multiforme. Cytostatics, irradiation and contemporary targeted chemotherapy are almost ineffective against cancer stem cells.
The idea is to use radiation simultaneously with drugs that suppress DNA retrieval process in cancer cells, followed by chemotherapy, one of the strategic objectives of which is to attack cancer stem cells.
The scientist emphasized that for the first time they have managed to study proteins that form the WNT signaling pathway and directly interact with its components in human CD133 + stem cells of glioblastoma multiforme.
It is observed that set of protiens (Proteome) in glioblastoma stem cells differs fundamentally from the one in other types of tumor cells
Fortunately the scientists have also identified other potential targets, the huge suppression of which can lead to an improvement of complex antitumor therapy results. These results require comprehensive and more in-depth research.
The best laboratories of the world are working towards these glioblastoma cancer stem cells which are difficult to treat and identify.
Research threats that cancer stem cells act with full potential when building up a bloodstream of a tumor with the exponential growth rate.
Anti-angiogenic therapy’s effectiveness has been increased by suppression of WNT-signaling proteins. The treatment glioblastoma stem cells differs fundamentally from the one in other types of tumor cells
Therapy like this is an important part for the effective treatment of glioblastoma and brain cancer. These results of studies will be implemented into clinical practice in the near future.
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